Aviptadil richt zich op de cytokine-storm die fatale ademnood veroorzaakt in COVID-19

• De dood van coronavirus (COVID-19) wordt voornamelijk veroorzaakt door het Acute Respiratory Distress Syndrome (ARDS), waarbij ernstige ontstekingen ervoor zorgen dat de longen zich vullen met vocht en zelfs mechanische beademing niet in staat is het leven te behouden. Het syndroom wordt gedeeltelijk veroorzaakt door een Cytokine Storm die wordt losgelaten door virale deeltjes.
• Van VIP is bekend dat het krachtige anti-cytokine-effecten heeft in tal van diermodellen en in fase 1- en fase 2-studies bij mensen

GENÈVE– (BUSINESS WIRE) – RELIEF THERAPEUTICS Holding AG (ZES: RLF) “Relief” kondigt aan dat het met zijn medicijn Aviptadil nu klinische proeven van de FDA is begonnen in het Thomas Jefferson University Hospital in Philadelphia voor de behandeling van Acute Respiratory Distress Syndrome (ARDS) in COVID -19. De multicenter-studie zal patiënten inschrijven die al mechanische beademing hebben, in de hoop dat Aviptadil de mortaliteit in deze aandoening kan verminderen en het vermogen van de long van de patiënt om zuurstof naar het lichaam over te dragen, helpt verbeteren.

“We zijn verheugd een van de weinige centra te zijn die de klinische studie van Aviptadil hebben gestart bij patiënten met door COVID-19 geïnduceerde acute respiratoire distress (ARDS). Deze studie richt zich op patiënten die de kern vormen van de crisis van ons land, namelijk degenen die mechanische beademing krijgen en die al maximale conventionele therapie krijgen. Als dit lukt, hopen we dat behandelingen zoals Aviptadil de overlevingskansen van deze patiënten kunnen veranderen, ‘zei professor Ross Summer, MD, afdelingshoofd van de afdeling Critical Care van het Thomas Jefferson University Hospital, die als hoofdonderzoeker voor deze site fungeert. 

Relief Therapeutics (RLF:SIX) Drug Aviptadil Enters FDA Trial at Thomas Jefferson University Hospital in Philadelphia, to Treat COVID-19-induced Acute Respiratory Distress

Aviptadil targets the cytokine storm that causes fatal Respiratory Distress in COVID-19

• Coronavirus (COVID-19) death is primarily caused by Acute Respiratory Distress Syndrome (ARDS), in which severe inflammation causes the lungs to fill with fluid and even mechanical ventilation is unable to maintain life. The syndrome is caused, in part, by a Cytokine Storm unleashed by viral particles.
• VIP is known to have potent anti-cytokine effects in numerous animal models and in phase 1 and phase 2 human studies

GENEVA–(BUSINESS WIRE)– RELIEF THERAPEUTICS Holding AG (SIX:RLF) “Relief” announces that its drug Aviptadil has now entered FDA clinical trials at Thomas Jefferson University Hospital in Philadelphia for the treatment of Acute Respiratory Distress Syndrome (ARDS) in COVID-19. The multicenter trial will enroll patients who are already on mechanical ventilation in the hopes that Aviptadil can decrease mortality in this condition and help to improve the ability of the patient’s lung to transfer oxygen to the body.

“We are delighted to be one of the few centers initiating the clinical study of Aviptadil in patients with COVID-19 induced Acute Respiratory Distress (ARDS). This study focuses on patients who are at the heart of our nation’s crisis, namely those receiving mechanical ventilation and that are already receiving maximal conventional therapy. If successful, we hope that treatments such as Aviptadil may change the chances of survival of these patients,” said Professor Ross Summer, MD, Section Chief of the Critical Care Division of Thomas Jefferson University Hospital, who is serving as principal investigator for this site.

The trial is being led by Relief’s US partner, NeuroRx, Inc., whose clinical operations are based in Radnor, PA, under FDA Investigational New Drug clearance, as part of the FDA’s Corona Treatment Acceleration Program (CTAP). Details of the study are posted on clinicaltrials.gov NCT04311697.

Death in COVID-19-infected patients is caused in part by a “cytokine storm” in the lungs, in which the virus triggers inflammatory molecules called “cytokines,” which cause the air sacs (alveolae) of the lungs to fill with water and become impermeable to oxygen, even in the setting of mechanical ventilation. VIP is a naturally synthesized peptide which is 40% concentrated in the lungs and which has been shown to have a potent anti-cytokine activity in numerous animal models of respiratory distress, acute lung injury, and inflammation. It has a 20-year history of safe use in human beings in multiple human trials for sarcoidosis, pulmonary fibrosis, and pulmonary hypertension, and is marketed in Europe as a local injection to treat erectile dysfunction.

Relief Therapeutics holds FDA and EU orphan drug designations for the use of VIP to treat ARDS, pulmonary hypertension, and sarcoidosis. Relief also holds a US patent¹ for Aviptadil and proprietary manufacturing processes for its synthesis.

“In a previous trial of VIP for ARDS in patients with sepsis, 7 of 8 patients on mechanical ventilation showed substantial improvement and 6 ultimately left the hospital alive,” said Prof. Jonathan Javitt, MD, MPH, the CEO of NeuroRx, Inc. “Patients on ventilators for COVID-19 have only a 50% chance of survival. If the early results can be replicated in ARDS caused by COVID-19, this treatment could have a major impact both on COVID-19 survival and on the availability of ventilators for those in desperate need.”

About RELIEF THERAPEUTICS Holding AG

The Relief group of companies focus primarily on clinical-stage projects based on molecules of natural origin (peptides and proteins) with a history of clinical testing and use in human patients or a strong scientific rational. Currently, Relief is concentrating its efforts on developing new treatments for respiratory disease indications.

About RLF-100

RLF-100 (Aviptadil) is a patented formulation of Vasoactive Intestinal Polypeptide (VIP) that was originally developed and is currently marketed in Europe for the treatment of erectile dysfunction. VIP is known to be highly concentrated in the lung and to inhibit a variety of inflammatory cytokines. Aviptadil was awarded Orphan Drug Designation in 2001 by the US FDA for treatment of Acute Respiratory Distress Syndrome and in 2005 for treatment of Pulmonary Arterial Hypertension. Aviptadil was awarded Orphan Drug Designation by the European Medicines Agency in 2006 for the treatment of Acute Lung Injury and in 2007 for the treatment of Sarcoidosis. Both the US FDA and the EMEA have granted Investigational New Drug licenses for human trials of Aviptadil.

RELIEF THERAPEUTICS Holding AG is listed on the SIX Swiss Exchange under the symbol RLF. For further information, please visit the Relief website at www.relieftherapeutics.com or contact at contact@relieftherapeutics.com

Disclaimer: This communication expressly or implicitly contains certain forward-looking statements concerning RELIEF THERAPEUTICS Holding AG, NeuroRx, Inc. and their businesses. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of RELIEF THERAPEUTICS Holding AG and/or NeuroRx, Inc. to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. RELIEF THERAPEUTICS Holding AG is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.

¹ US 8,178,489 Formulation for Aviptadil

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Contacts

Yves Sagot

Contact@relieftherapeutics.com