In de presentaties wordt de leidende molecule KB-3061 beschreven als een potentiële precisiegeneeskunde voor een zeldzame pediatrische epilepsie

PITTSBURGH– (BUSINESS WIRE) – Knopp Biosciences LLC, een particulier bedrijf voor het ontdekken en ontwikkelen van geneesmiddelen gericht op het leveren van doorbraakbehandelingen voor immunologische en neurologische ziekten met een hoge onvervulde behoefte, heeft vandaag aangekondigd dat gegevens van zijn Kv7-platform zullen worden gepresenteerd op de American Epilepsy Society’s (AES) 2019 jaarvergadering van 6-10 december in Baltimore.

“We kijken uit naar het delen van de voortgang van ons belangrijkste kandidaat-medicijn voor de behandeling van KCNQ2-epileptische encefalopathie, terwijl we het begrip van ionkanaalactivatoren en de belangrijke rol die ze spelen bij epilepsie en andere neurologische aandoeningen met een grote onvervulde behoefte bevorderen”, zei Michael Bozik, MD, Chief Executive Officer van Knopp Biosciences.

Knopp Biosciences to Present Data Characterizing Its Potassium Channel Activator Candidate for the Treatment of KCNQ2 Epileptic Encephalopathy at the American Epilepsy Society’s 2019 Annual Meeting

Presentations will detail lead molecule KB-3061 as a potential precision medicine treatment for a rare pediatric epilepsy

PITTSBURGH–(BUSINESS WIRE)– Knopp Biosciences LLC, a privately held drug discovery and development company focused on delivering breakthrough treatments for immunological and neurological diseases with high unmet need, today announced that data from its Kv7 platform will be presented at the American Epilepsy Society’s (AES) 2019 Annual Meeting from December 6-10 in Baltimore.

“We look forward to sharing progress on our lead drug candidate for the treatment of KCNQ2 epileptic encephalopathy as we advance the understanding of ion channel activators and the important role they play in epilepsy and other neurological conditions with high unmet need,” said Michael Bozik, M.D., Chief Executive Officer of Knopp Biosciences.

Ion channels are proteins that regulate the excitability of cells, and drugs that modulate ion channels play an important role in treating a variety of neurological and smooth muscle conditions. Among ion channel targets, potassium channels play a key role in the pathophysiology of epilepsy and other unmet needs in diseases of the nervous system. Knopp is advancing a library of Kv7.2/7.3 channel activators to modulate this key ion channel in nerve cells, targeting a devastating genetic mutation associated with neonatal encephalopathy, as well as other rare epilepsies and neuropathic pain.

Details related to Knopp Biosciences’ AES abstracts and poster presentations can be found in the table below.

Follow Knopp Biosciences on Twitter via @KnoppBio and keep up to date with AES Annual Meeting news and updates using the hashtag #AES2019.

ABOUT KNOPP BIOSCIENCES LLC

Knopp Biosciences is a privately held drug discovery and development company focused on delivering breakthrough treatments for immunological and neurological diseases of high unmet need. Knopp’s clinical-stage small molecule, dexpramipexole, is in Phase 2 clinical trials for severe eosinophilic asthma. Knopp’s preclinical Kv7 platform is directed to small molecule treatments for neonatal epileptic encephalopathy, other rare epilepsies, and neuropathic pain. Please visit www.knoppbio.com.

Knopp’s Kv7 research is supported under Award Number U44NS093160 and Award Number U44NS115732 of the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH). The content of this announcement is solely the responsibility of Knopp and does not necessarily represent the views of the NIH.

This press release contains “forward-looking statements,” including statements relating to planned regulatory filings and clinical development programs. All forward-looking statements are based on management’s current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including the uncertainties inherent in clinical trials and product development programs, the availability of funding to support continued research and studies, the availability or potential availability of alternative therapies or treatments, the availability of patent protection for the discoveries and strategic alliances, as well as additional factors that may cause Knopp’s actual results to differ from our expectations. There can be no assurance that any investigational drug product will be successfully developed or manufactured or that final results of clinical studies will be supportive of regulatory approvals required to market a product. Knopp undertakes no obligation to update or revise any such forward-looking statements, whether as a result of new information, future events or otherwise.

Knopp’s pipeline consists of investigational drug products that have not been approved by the U.S. Food and Drug Administration. These investigational drug products are still undergoing clinical study to verify their safety and effectiveness.

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